Simostress

Simostress Tablets are standardized to contain 2.3 mg of flavonol (calculated as hyperoside) per tablet.

Composition Per Tablet

• Hops Flower Extract (Humulus lupulus): 25 mg
• Chamomile Flower Extract (Matricaria chamomilla): 25 mg
• Valerian Root Extract (Valeriana officinalis): 25 mg
• Passionflower Aerial Part Extract (Passiflora incarnata): 25 mg
• Vitamin C (Ascorbic Acid): 166.66 mg
• Vitamin B1 (Thiamine Hydrochloride): 25 mg
• Vitamin B2 (Riboflavin): 25 mg
• Niacinamide (Vitamin B3): 10 mg
• Vitamin B6 (Pyridoxine Hydrochloride): 25 mg
• Folic Acid: 33.33 mcg
• Vitamin B12 (Cyanocobalamin): 20 mcg
• Biotin: 20 mcg
• Pantothenic Acid (Calcium Pantothenate): 16.66 mg
• Calcium (as Dicalcium Phosphate): 200 mg
• Magnesium (as Magnesium Oxide): 100 mg
• Choline Bitartrate: 16.66 mg
• Inositol: 16.66 mg
• Para-aminobenzoic Acid (PABA): 16.66 mg

Therapeutic Properties

Helps reduce stress and anxiety.

Dosage and Administration

Adults: Take 1 tablet three times daily, preferably with meals, or as directed by a physician.

Adverse Effects

Possible side effects may include:

• Headache
• Dizziness
• Gastrointestinal disturbances (e.g., heartburn, diarrhea, nausea, indigestion, or loss of appetite).

Contraindications and Precautions

• Not recommended during pregnancy or lactation.
• Contains valerian and passionflower, which can enhance CNS depressant effects. Avoid concurrent use with sedatives such as benzodiazepines (e.g., alprazolam).
• Use cautiously in individuals with hypotension or those sensitive to hormonal changes.
• Avoid in patients with:
  • Gastrointestinal obstruction
  • Hemophilia
  • Hormone-sensitive conditions
• Discontinue use two weeks prior to surgery.
• Consult a physician before use in individuals under 18 years of age.

Drug Interactions

Simostress may interact with:

• Antibiotics
• Oral contraceptives
• Anticoagulants
• Diuretics
• CNS depressants

Pharmacological Effects and Mechanism of Action

• Valerian Root: Demonstrates sedative and anxiolytic properties. Clinical studies confirm its role in reducing stress and improving sleep latency and quality.
• Chamomile Flower: Contains matricin, bisabolol, and apigenin, which exhibit anti-inflammatory and anxiolytic effects by interacting with benzodiazepine receptors.
• Passionflower: Acts as an anxiolytic, sedative, analgesic, and antispasmodic. It reduces aggression, restlessness, and enhances pain tolerance through its alkaloids and compounds such as maltol.
• Hops Flower: Proven sedative properties linked to compounds like 2-methyl-3-buten-2-ol and isovaleric acid.
• B Vitamins: Essential for neurotransmitter function (e.g., serotonin production) and CNS health. Deficiencies may cause anxiety, depression, and fatigue.
• Calcium and Magnesium: Crucial for neurological stability; deficiencies are linked to anxiety and stress. Magnesium is often used in anxiety management.
• Vitamin C: Supports adrenal function during stress. Deficiency may result in fatigue, irritability, and anxiety.

Storage Conditions

• Store below 30°C, protected from light and moisture.
• Keep out of reach of children.