Relaxim

General Drug Information

Anti-Stress
Natural Product
Dosage Form: Oral Drops
Packaging: 30 mL bottle with an informational leaflet in a cardboard box.

Ingredients and Active Components

Each 1 mL of Relaxim Oral Drops (Simorgh Darou) contains:

• Tincture of Valerian Root (Valeriana officinalis): 0.5 mL
• Tincture of Hops Flowers (Humulus lupulus): 0.5 mL

Standardized to contain 0.075 mg of Valerenic Acid per mL.

Indications

Reduction of stress and anxiety symptoms

Dosage and Administration

Adults:

• Dilute 10–20 drops in a small amount of water, 1–2 times daily, or as directed by a physician.
• Shake the bottle well before use.

Precautions and Contraindications

• Consult your physician or pharmacist before use if you are taking any medications, supplements, or herbal products, or if you have chronic illnesses.
• Avoid use if hypersensitive to any ingredient in the formulation.
• Contraindicated during pregnancy and lactation.
• For individuals under 18 years, consult a physician before use.
• Do not exceed the recommended dosage.

Side Effects

While this product is generally safe, it may cause the following side effects in some individuals:

• Drowsiness
• Headache
• Gastrointestinal discomfort
• Irritability

In case of long-term use, taper the dosage gradually under medical supervision. If any of these side effects occur, consult your physician or pharmacist.

Drug Interactions

• Valerian in this product may interact with alprazolam and other CNS depressants, potentially leading to enhanced sedative effects.
• Valerian may also inhibit weak glucuronidation, increasing the concentration of drugs metabolized through this pathway.

Pharmacological Effects and Mechanism of Action

The medicinal parts of valerian are its roots and rhizomes. Valerian exhibits:

• Sedative
• Hypnotic
• Anxiolytic
• Antidepressant
• Anticonvulsant
• Antispasmodic properties

Human studies confirm the sedative effects of valerian, demonstrating its ability to:

• Reduce sleep onset time
• Improve irregular sleep patterns
• Minimize night awakenings
• Enhance overall sleep quality

Hops flowers demonstrate sedative effects in animal studies. Their calming effects are attributed to alpha-bitter acids, beta-bitter acids, and the presence of volatile oils. Post-oral administration, lupulone may be converted to 2-methyl-3-buten-2-ol, contributing to sedative effects. Additionally, residual isovaleric acids in hops may play a role in these properties.

Pregnancy and Lactation

This product should not be used during pregnancy or lactation.