Simosleep

Simosleep Tablets contain 5 mg of melatonin combined with natural herbal sedatives.

Product Advantages

• Non-prescription and non-habit forming
• High efficacy in improving sleep quality

Dosage Form and Packaging

Dosage Form: Tablets
Packaging: 3 blister packs of 10 tablets in a cardboard box with a patient information leaflet

Composition Per Tablet

• Valerian Root Powder (Valeriana officinalis): 100 mg
• Chamomile Flower Powder (Matricaria chamomilla): 50 mg
• Hops Flower Powder (Humulus lupulus): 50 mg
• Passionflower Aerial Part Powder (Passiflora incarnata): 25 mg
• Taurine: 50 mg
• Melatonin: 5 mg
• Calcium Carbonate: 124.865 mg (equivalent to 50 mg elemental calcium)
• Magnesium Oxide: 41.465 mg (equivalent to 25 mg elemental magnesium)

Indications

• Assists in treating insomnia
• Aids in regulating sleep during long-distance travel
• Helps alleviate melatonin deficiency-related depression
• Exhibits antioxidant and anti-cancer properties

Pharmacological Effects and Mechanism of Action

1. Valerian Root: Acts as a sedative, hypnotic, anxiolytic, antidepressant, anticonvulsant, and antispasmodic. Clinical studies demonstrate its sedative effects, reduction in sleep onset latency, and improvement in sleep quality. It also addresses sleep irregularities and reduces night awakenings.
2. Chamomile Flower: Contains apigenin, which binds to benzodiazepine receptors, contributing to its sedative and sleep-inducing properties.
3. Passionflower Extract: Has a central nervous system depressant effect, improving insomnia symptoms.
4. Melatonin: A naturally occurring hormone produced by the pineal gland, regulates the body’s circadian rhythm and sleep-wake cycles. Melatonin production is influenced by light-dark cycles.

Dosage and Administration

Adults: Take 1 tablet daily, 30 minutes to 1 hour before bedtime.

Side Effects

When used at the recommended dose, this product is free from significant side effects.

Drug Interactions

• Concurrent use with sedatives or hypnotics is not advised due to additive effects.
• Consult a physician before use if taking:
  • Anticoagulants
  • Immunosuppressants
  • Antihypertensive medications

Use During Pregnancy and Lactation

Not recommended during pregnancy or lactation.

Precautions and Contraindications

• Not recommended for:
  • Pregnant and breastfeeding women
  • Individuals under 18 years of age
• Avoid driving or operating heavy machinery after use.
• Hops is contraindicated in patients with depression and should be avoided in women with breast cancer due to its estrogenic-like effects.
• Discontinue use at least 2 weeks prior to surgery due to the presence of hops.