Simovit calcium-vitamin D3

General Information for Simovit Calcium + Vitamin D3

Dosage Form: Syrup
Packaging: 200 mL bottle with a consumer instruction leaflet in a cardboard box

Active Ingredients (per 5 mL of solution):

Vitamin D3 (Cholecalciferol): 300 IU

Calcium (as Calcium Carbonate): 250 mg (equivalent to 625.5 mg Calcium Carbonate)

Other Ingredients: Glycerin, Potassium Sorbate, Sucralose, Citric Acid, Orange Essence, Purified Water

Indications

Supporting bone health

Dosage and Administration

Children (1–8 years): 5 mL twice daily

Children (9–18 years) and Adults: 5 mL three times daily, or as directed by a physician.
Shake the bottle well before use.

Precautions and Contraindications

Do not exceed the recommended dosage.

If you are taking any other medications or supplements, or have chronic illnesses, consult your physician or pharmacist before use.

Discontinue use if allergic to any component of the product.

This product is a dietary supplement and is not intended for the diagnosis, prevention, or treatment of disease.

Shake the bottle well before use.

The ideal time to take this product is 1 to 2 hours after meals or other oral medications, unless otherwise directed by your healthcare provider.

Consult a physician before using this product if you are taking other supplements containing high amounts of calcium, magnesium, or vitamin D3, or if you have conditions such as gastrointestinal disorders, cardiovascular disease, hypercalcemia, elevated urinary calcium, hypoparathyroidism, hyperparathyroidism, sarcoidosis, kidney disease, or a history of kidney stones.

Side Effects

Calcium supplements, when taken as directed, are generally safe. However, potential side effects may include nausea, vomiting, constipation or diarrhea, and bloating.

Drug Interactions

Certain antibiotics (e.g., Ciprofloxacin, Tetracycline, Levofloxacin, Doxycycline, Minocycline) and medications such as Levothyroxine and Verapamil may interact with this product due to the calcium content, as calcium can reduce the absorption of these drugs. It is recommended to take these medications at least 2 hours before or 4-6 hours after taking calcium.

Bisphosphonates (e.g., Alendronate) may also interact with this product, as calcium can reduce their absorption. These should be taken separately.

For individuals at risk of iron deficiency, it is recommended to take calcium supplements at night to avoid interference with iron absorption.

Concurrent use of aluminum-containing medications with Vitamin D may lead to increased aluminum levels in the blood, particularly in patients with chronic kidney failure.

Thiazide diuretics (e.g., Hydrochlorothiazide) may interact with this product due to its calcium content, potentially increasing serum calcium levels.

Pharmacological Effects and Mechanism of Action

Over 99% of calcium in the human body is stored in bones and teeth. A decrease in estrogen levels in women leads to reduced calcium absorption and decreased bone mass.

The regulation of plasma calcium and phosphorus levels is primarily dependent on Vitamin D, which enhances calcium absorption from the intestines.

Vitamin D is crucial for calcium balance and bone health, playing a role in osteoporosis prevention. It also contributes to muscle strength and neuromuscular function, thereby supporting bone health.

Use During Pregnancy and Lactation

This product may be used during pregnancy and lactation as directed by a physician.

Storage Conditions

Store the product in its original box, away from light and moisture, at a temperature below 30°C. Keep out of reach of children.

Frequently Asked Questions

What are the side effects of this product?
Side effects may include nausea, vomiting, constipation, diarrhea, and bloating.

Does this product have drug interactions?
Yes, this product may interact with certain antibiotics, calcium, and iron supplements.