Simoprostate

Manufacturer: Simorgh Darou
Purpose: Prostate health dietary supplement.

Dosage Form and Packaging

• Formulation: Capsule
• Packaging: Two blisters, each containing 15 capsules, with an informational leaflet in a cardboard box.
• Standardization: Each capsule contains 58.3 mg total amino acids.

Composition (Per Capsule)

• Saw Palmetto Fruit Extract (Serenoa repens): 33.213 mg
• Rye Grass Flower Extract (Secale cereale): 33.83 mg
• Pumpkin Seed Extract (Cucurbita pepo): 66.66 mg
• Nettle Root Extract (Urtica dioica): 66.66 mg
• Phytosterol Complex: 33.83 mg
• Zinc Citrate Dihydrate: 363.10 mg
• Lycopene: 66.1 mg
• Selenomethionine: 0.082 mg

Indications

• Maintains the natural size of the prostate gland.
• Promotes normal urinary flow in men.
• Supports the management of benign prostatic hyperplasia (BPH), urinary frequency, pain, and burning during urination.
• Helps prevent androgenic hair loss in men.

Dosage and Administration

Adults: Take three capsules daily, either simultaneously or divided across meals, with food and water, or as directed by a physician.

Pharmacological Effects and Mechanism of Action

Pumpkin Seed Extract:

• Rich in phytosterols, enhances urinary flow, reduces bladder discomfort, and alleviates prostate swelling without decreasing gland size.

Rye Grass Extract:

• Improves urinary flow and enhances bladder muscle contraction.
• May act on alpha-adrenergic receptors, relaxing the bladder’s internal and external muscles.

Saw Palmetto Extract:

• Inhibits 5-alpha reductase, reducing dihydrotestosterone (DHT) production.
• Alleviates symptoms of BPH, such as frequent urination, incomplete bladder emptying, and pain during urination.
• Effective in controlling androgenic alopecia by reducing DHT activity.

Nettle Root Extract:

• Modulates testosterone metabolism and reduces its binding to prostate tissue.
• Beta-sitosterol content inhibits prostaglandin synthesis, reducing prostate inflammation and enlargement.

Lycopene:

• A carotenoid with anti-inflammatory properties found in foods like tomatoes.
• May also lower lipid levels.

Adverse Effects

While generally well-tolerated, the following may occur in rare cases:

• Gastrointestinal disturbances.
• Allergic reactions such as hives or itching.

If adverse effects occur, discontinue use and consult a healthcare provider.

Drug Interactions

• Anticoagulants and Antiplatelet Agents (e.g., warfarin, aspirin): Potential for increased bleeding risk.
• Antidiabetic Medications: Nettle may increase the risk of hypoglycemia.
• Antihypertensives: Potential additive effects.
• Hormonal Contraceptives: Saw palmetto may interact due to anti-estrogenic properties.
• Calcium and Lutein Supplements: Possible interaction with phytosterols.

Avoid concurrent use with these medications unless supervised by a healthcare professional.

Precautions and Contraindications

• Consult a healthcare provider before use if taking medications, supplements, or herbal products, or if you have chronic medical conditions.
• Do not use if allergic to any ingredients.
• Use in women is limited to androgenic hair loss cases, where it is contraindicated during pregnancy and lactation.
• Diabetics: Use with caution due to the potential hypoglycemic effect of nettle.
• This product is a supplement and not intended for the diagnosis, treatment, or prevention of disease.