Simopain

Product Name: Simopain Topical Cream (Simorgh Darou)
Packaging: 30g Tube containing Topical Cream with Instruction Leaflet in a Cardboard Box

Composition (Active Ingredients)

Each 1g of Simopain Cream contains:

• Arnica Flower Extract: 0.88 mg
• Calendula Officinalis (Marigold) Flower Extract: 0.046 mg
• Hypericum Perforatum (St. John’s Wort) Flower Extract: 0.2 mg
• Mentha Piperita (Peppermint) Oil: 20 mg

Other Ingredients:

• Vaseline
• Cetyl Alcohol
• Stearic Acid
• Glycerin
• Beeswax
• Lanolin
• Propylparaben
• Methylparaben
• Water

Standardized based on 11 mg Menthol per 1g of Cream.

Indications

Simopain Topical Cream is indicated for:

• Relief of localized pain

Dosage and Administration

Recommended Application: Apply an adequate amount of cream to the affected muscle or area of injury. This can be repeated 3 to 4 times daily or as directed by a healthcare provider.

Precautions and Contraindications

• Eye Contact:
  Avoid contact with eyes.
• Allergic Reaction:
  If you are allergic to any of the ingredients in this product, discontinue use. It is recommended to perform a patch test by applying a small amount on the inner forearm. If any skin irritation occurs, avoid further use.
• Wounds and Infections:
  Do not apply the cream on open wounds, cuts, or areas with infections.
• Sensitive Areas:
  Due to the presence of menthol in peppermint oil, avoid applying this product to sensitive areas around the face or chest, especially in infants or young children, particularly near the nose.
• External Use Only:
  For external use only. Keep away from children.

Side Effects

Simopain is generally well tolerated, but in some cases, it may cause:

• Skin reactions such as itching, redness, irritation, or peeling.
• St. John’s Wort contains red pigments (Hypericin), which may rarely cause photosensitivity (sensitivity to light).

Drug Interactions

No known drug interactions with this product.

Pharmacological Effects and Mechanism of Action

• Calendula: Research has shown that rutin inhibits the release of histamine and serotonin, reducing vascular permeability. These mediators are released during inflammation from platelets, mast cells, and basophils, leading to increased vessel permeability. The flavonoids in Calendula contribute to anti-inflammatory effects by impacting arachidonic acid metabolism. Quercetin and rutin inhibit lipid peroxidation in a non-enzymatic manner. Additionally, aglycones of flavonoids inhibit prostaglandin synthesis through the cyclooxygenase pathway, reducing inflammation.
• St. John’s Wort (Hypericum Perforatum): This herb has anti-inflammatory, antispasmodic, and permeability-modulating effects due to its flavonoid content.
• Arnica: The active ingredients in Arnica, sesquiterpene lactones, provide anti-inflammatory and analgesic effects.
• Peppermint: Menthol in peppermint oil has well-established topical analgesic and irritant effects. When applied to the skin, menthol stimulates cold receptors while suppressing pain receptors. It also reduces muscle spasms caused by serotonin.

Use in Pregnancy and Lactation

Due to the lack of sufficient data on the safety of this product during pregnancy and breastfeeding, its use should be avoided during these periods.