Sim Fat Liver

Formulation

Dosage Form: Film-coated tablets.
Packaging: 30 tablets in three blister packs (10 tablets each) with a patient information leaflet enclosed in a cardboard box.

Each tablet contains

• Artichoke Leaf Dry Extract (Cynara scolymus): 300 mg
• Milk Thistle Seed Powder (Silybum marianum): 150 mg
  • Standardized to 17.85 mg of caffeoylquinic acid per tablet.

Other Ingredients:

• Magnesium stearate
• Talc

Indications

• Enhances fat metabolism.
• Stimulates bile production.
• Improves digestion.

Dosage and Administration

• Take 1 tablet 3-4 times daily, or as directed by a healthcare professional.

Precautions and Contraindications

• Medical Consultation: If you are taking any medication, supplements, or herbal products, or if you have conditions such as gallstones, bile duct obstruction, or chronic illnesses (e.g., cancer), consult your physician or pharmacist before use.
• Allergic Reactions: Avoid use if allergic to any of the ingredients.
• Supplement Disclaimer: This product is a dietary supplement and not intended to diagnose, prevent, or treat any disease.

Adverse Effects

This product is generally safe when used as directed. However, mild gastrointestinal side effects may occur, including:

• Abdominal pain
• Diarrhea
• Bloating
• Hunger
• Indigestion
• Nausea

If you experience these or any other adverse effects, discontinue use and consult a healthcare professional.

Drug Interactions

• Artichoke and Milk Thistle: May increase the risk of hypoglycemia when combined with antidiabetic medications.
• Milk Thistle:
  • Interacts with warfarin, tamoxifen, sirolimus, morphine, and other drugs, potentially enhancing their effects.
  • Increases serum levels of drugs metabolized via CYP2C9, such as cannabinoids, carvedilol, bosentan, celecoxib, warfarin, and phenytoin.
  • May elevate blood levels of deferiprone and sirolimus.

Recommendation: Consult your physician if you are using any of the above medications before taking this supplement.

Pharmacological Effects and Mechanism of Action

Artichoke Extract:

• May reduce cholesterol synthesis by inhibiting HMG-CoA reductase, attributed to compounds like cynaroside and luteolin.

Milk Thistle Extract:

• Prevents oxidation of LDL cholesterol through its antioxidant properties and radical-scavenging activity.
• Inhibits cholesterol acyltransferase, reducing cholesterol absorption and lipoprotein biosynthesis.
• Reduces myeloperoxidase (MPO) in hyperlipidemic patients.
• Demonstrates lipid-modulating effects, including:
  • Decreasing VLDL and LDL levels.
  • Increasing HDL cholesterol levels.

Use During Pregnancy and Lactation

Use under medical supervision during pregnancy and breastfeeding.

Storage Conditions

• Store in its original packaging, protected from light and humidity, at temperatures below 30°C.
• Keep out of reach of children.