SIMOSPAN

Dosage Form: Syrup
Packaging: 120 mL bottle in a cardboard box, accompanied by a patient information leaflet.

Active Ingredients in Simospan Cough Syrup

• Thyme Liquid Extract: 840 mg
• Ivy (Hedera helix) Tincture: 84 mg
• Honey: 500 mg
• Vitamin C: 10 mg

Standardized to contain 1.05 mg of Thymol.

Indications for Use

Simospan Cough Syrup is indicated for:

• Relief of cough
• Treatment of bronchitis
• Expectorant action
• Alleviation of inflammation in the respiratory tract

Dosage and Administration

• Children (2–5 years): 3 mL, three times daily.
• Children (6–11 years): 5 mL, three times daily.
• Adults and children aged 12 years and older: 6 mL, three times daily.

Shake the bottle well before use.

Pharmacological Effects and Mechanism of Action

Thyme (Thymus vulgaris)

Thyme has long been used for reducing and relieving coughs without significant side effects. Its antitussive and expectorant properties are attributed to its volatile oils, particularly thymol and carvacrol, which enhance the movement of respiratory cilia and stimulate mucosal secretions. The extract increases mucus secretion in the respiratory tract and promotes the expulsion of waste, microbes, and particles via the respiratory pathways. Its spasmolytic effects on the ileum and bronchi are due to its influence on histamine and acetylcholine secretion. Thyme extract also exhibits antibacterial and antifungal properties owing to its phenolic compounds.

Ivy (Hedera helix)

Ivy extract acts as an expectorant, anti-inflammatory agent, and mucolytic, aiding in the reduction of mucus viscosity. It effectively reduces cough frequency and severity, particularly spasmodic coughs. Ivy’s beneficial effects are linked to its saponin compounds, especially α-hederin, which demonstrate secretolytic and bronchodilatory activities.

Honey

Honey serves as a natural remedy for cough associated with bronchitis. Its antiviral and antibacterial properties provide soothing effects for the throat, and it also strengthens the immune system.

Side Effects

No significant side effects have been reported when the recommended dosage is followed. In rare cases, individuals may experience mild gastrointestinal irritation due to the herbal components.

Drug Interactions

No adverse interactions have been reported when used concurrently with other medications, including antibiotics.

Use During Pregnancy and Lactation

Due to insufficient reliable data, use during pregnancy and breastfeeding is not recommended.

Contraindications and Precautions

• Avoid use in severe gastrointestinal disorders or known allergies to thyme or ivy.
• In cases of severe skin damage, acute skin diseases, high fever, severe infections, or cardiac conditions, consult a physician before use.
• Sediments in the syrup do not indicate a lack of efficacy or quality; shake well before use.
• Contains 0.5–0.6% alcohol; consult your physician if this is a concern.
• Do not exceed the recommended dose, as excessive ivy consumption may cause toxicity.
• Overdose may lead to gastrointestinal discomfort, dizziness, headache, or mental confusion. Discontinue use and seek medical attention if these symptoms occur.

Sweeteners Used

The syrup contains sucralose and natural honey as sweeteners.

Storage Conditions

• Store below 30°C, away from light and moisture. Protect from freezing.
• Keep out of reach of children.
• After opening, the product can be used for up to one month if stored below 30°C.