Calmerz K2

Calcium + Magnesium + Zinc + Vitamin D3 + Vitamin K2 Tablets

Packaging:

The product is provided in a pack containing 3 blister strips of 10 tablets each, accompanied by a patient information leaflet enclosed within a carton box.

Active Ingredients:

Each tablet of Calmerz K2 by Simorgh Darou Pharmaceutical contains:

• Calcium (from 999 mg of calcium carbonate): 400 mg
• Magnesium (from 359.9 mg of magnesium hydroxide): 150 mg
• Zinc (from 13.7 mg of zinc sulfate): 5 mg
• Vitamin D3 (Cholecalciferol): 400 IU
• Vitamin K2 (Menaquinone): 50 µg

Excipients: Microcrystalline cellulose, povidone, magnesium stearate, croscarmellose sodium, and corn starch.

Indications:

This supplement is intended for:

• Prevention and treatment of osteoporosis and osteomalacia.
• Reducing calcium deposition in blood vessels, making it suitable for cardiac patients.

Dosage and Administration:

• Recommended Dose: One tablet twice daily, preferably after meals, with a glass of water.
• Follow the dosage as prescribed by a healthcare professional.

Pharmacology and Mechanism of Action:

• Calcium:
  Over 99% of the body’s calcium is stored in bones and teeth. Post-menopausal women may experience reduced calcium absorption due to lower estrogen levels, leading to bone loss. Vitamin D plays a pivotal role in enhancing intestinal calcium absorption, ensuring calcium-phosphorus balance, and preventing osteoporosis.
• Vitamin D3:
  Supports calcium balance for bone health and enhances neuromuscular strength, which contributes to bone integrity.
• Vitamin K2:
  Activates proteins that facilitate the removal of calcium from blood vessels and its deposition in bones. This helps reduce the risk of cardiovascular diseases and arterial calcification while improving bone density.
• Zinc:
  Supports growth, immune functions, reproduction, and neurobehavioral development.
• Magnesium:
  Essential for the proper functioning of nerves, muscles, and the cardiovascular system.

Potential Side Effects:

When taken as directed, the product is generally well-tolerated. However, mild gastrointestinal side effects may occur, such as:

• Nausea and vomiting
• Constipation
• Abdominal pain
• Bloating
• Diarrhea

Drug Interactions:

• Antibiotics (e.g., ciprofloxacin, levofloxacin, doxycycline, minocycline):
  Calcium may reduce the absorption of these medications. Maintain at least a 2-hour gap before or 4-hour gap after taking this supplement.
• Bisphosphonates (e.g., alendronate):
  Calcium can decrease the absorption of bisphosphonates; take with a time interval.
• Iron:
  Calcium may interfere with iron absorption. Individuals at risk of iron deficiency should take calcium supplements at night to minimize interaction.
• Vitamin K2:
  As an antagonist to oral anticoagulants (e.g., warfarin), concurrent use may reduce the efficacy of these medications.
• Zinc:
  May theoretically enhance the effects of anti-diabetic medications.

Precautions:

• Do not exceed the recommended dosage.
• Consult your physician or pharmacist before use if you:
  • Have any medical conditions, including renal insufficiency, hypercalcemia, or hyperphosphatemia.
  • Are pregnant or breastfeeding.
  • Are on medications such as anticoagulants, iron supplements, or antibiotics.
• Avoid use if allergic to any ingredients in this supplement.

Use During Pregnancy and Lactation:

This supplement is safe for use during pregnancy and breastfeeding when taken under medical supervision.

Storage Conditions:

• Store in a cool, dry place away from light and moisture, at temperatures below 30°C.
• Keep out of reach of children and pets.

Frequently Asked Questions (FAQs):

1. What are the side effects of this supplement?
Mild gastrointestinal symptoms such as nausea, vomiting, constipation, abdominal pain, bloating, and diarrhea may occur.

2. Does this supplement interact with other medications?
Yes, it may interact with certain antibiotics, bisphosphonates, iron supplements, and anticoagulants like warfarin. Maintain appropriate time intervals between medications and consult your healthcare provider for guidance.